Reason has already a synth and a sampler built in. Just go download the demo version at http://www.propellerheads.se/download/i ... =mainframe
and play a bit with it.
The other things you need are:
- a decent audio interface (e.g. soundcard geared towards music production as opposed to gaming - so an E-mu 0404 or M-Audio Audiophile instead of an Audigy or X-Fi)
- a decent pair of monitor speakers (speakers that do not "color" the sound too much).
- a MIDI controller keyboard (a "dummy" keyboard that acts as a remote and doesn't have its own sounds).
What's your budget?
"Part of an instrument is what it can do, and part of it is what you do to it" - Suzanne Ciani, 197x.